Multiple choice

A doctor told a couple that their son is a patient of plasmablastic lymphoma which is a rare and aggressive variant of diffuse large B-cell lymphoma. Which among the following viruses causes hematologic malignancies in such patients?

  1. Cytomegalovirus

  2. Human herpes virus 5

  3. Human herpes virus 4

  4. Human herpes virus 3

  5. Kaposi's sarcoma herpes virus (HHV-8)

Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

HHV-8 infects lymphocytes and epithelial / endothelial cells and is the causative agent of Kaposi's sarcoma. It has also been associated with hematologic malignancies, including primary effusion lymphoma, multicentric Castleman's, MCD-related immunoblastic / plasmablastic lymphoma.

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