Multiple choice

Obesity is considered to be the result of the combination of deletions, SNPs and gene mutations. Which among the following does not characterise monogenic obesity?

  1. It occurs due to the congenital leptin deficiency.

  2. The common monogenic obesity disorder was represented by excess of MC4R.

  3. The phenotype is directly and strongly related to the genotype.

  4. In leptin melanocortin pathway, leptin crosses the blood brain barrier and triggers the neurons present in the hypothalamus to generate peptides.

  5. The receptor gene mutations might be one of the reasons for severe obesity.
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The mutation in the melanocortin-4 receptor protein (MC4R) which is a component of leptin-melanocortin pathway was detected to be related to obesity. The common monogenic obesity disorder was represented by MC4R deficiency. The obesity was accounted due to homozygous and heterozygous mutations in MC4R.

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