Multiple choice Which of the following causes an increase in renal potassium excretion? Loop diuretics Aldosterone Spironolactone Increased urine flow rates Thiazide diuretics Reveal answer Fill a bubble to check yourself C Correct answer Explanation Spironolactone opposes the actions of aldosterone and so, has the opposite effect. It is an aldosterone receptor antagonist that causes the kidneys to remove water and sodium from the body, with reduced losses of potassium.