Multiple choice Which of the following cause(s) a significant decrease in renal potassium excretion? Thiazide diuretics Increased urine flow rates Spironolactone Aldosterone Loop diuretics Reveal answer Fill a bubble to check yourself C Correct answer Explanation Spironolactone opposes the actions of aldosterone. It has the opposite effect. It is an aldosterone receptor antagonist that causes kidneys to remove water and sodium from the body, with reduced losses of potassium.