Multiple choice What is the function of C1 in the classical pathway of complement activation? Stimulates inflammation Initiates assembly of membrane attacking complex Initiates classical pathway Initiates alternative pathway Initiates lectin pathway Reveal answer Fill a bubble to check yourself C Correct answer Explanation Initiates classical pathway C1q binds to Fc portion of AB. C1r and C1s are proteases that lead to C4 and C2 activation.