Multiple choice

Multiple coding sequences are inserted in between the genes encoding for MHC-I and MHC-II. The insertions are genetically engineered so as to prevent any loss of function in individual genes. Such a model is then implemented in the biological offspring of a couple. Unfortunately, the child is born with rudimentary kidneys. A kidney transplant is required and doctors look for an advent match. Based on the above data, answer the following question. The doctors should look for matches in

  1. blood relatives to increase the chances

  2. outside blood relatives as the MHC expression will be different

  3. brothers and sisters because they would have got the exact tissue typing match

  4. parents, as they will be the best possible match in this condition
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B Correct answer
Explanation

When MHC genes are engineered to be different from both parents, blood relatives won't have matching MHC profiles. The genetic modifications create unique MHC combinations not present in the family. Therefore, doctors should look among non-relatives where the MHC might coincidentally match. Siblings and parents would NOT match because their natural MHC differs from the engineered genes.

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