Multiple choice Sickle-cell trait was selected by nature in whole Central Africa because it provides prominent immunity to chronic anemia it provides little immunity against malaria it provides little immunity against thalassemia it provides little immunity against gout Reveal answer Fill a bubble to check yourself B Correct answer Explanation The microscopic organisms that cause malaria are parasites on normal red blood cells. Full-blown sicklers produce abnormal and deformed red cells. As a result, they are poor hosts for this disease and are immune. However, they are frequently anemic.