Multiple choice The systemic lupus erythematosus (SLE) is characterised by a type III hypersensitivity an autoimmune disease a disease that often affects the skin a disease that often affects the kidneys a disease in which characteristically anti-DNA auto antibodies are present Reveal answer Fill a bubble to check yourself D Correct answer Explanation Although patients with SLE often develop an immune complex mediated glomerulonephritis, this is not the single best defining feature. Patients with SLE very characteristically possess anti-nuclear antibodies (ANA), including antibodies against DNA.