Multiple choice

What is the true condition about Dubin Johnson syndrome?

  1. UDP glucuronyl transferase is deficient

  2. UDP glucuronyl transferase is absent

  3. Uptake by liver is defective

  4. Transport into the biliary system is defective
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Dubin-Johnson syndrome is a conjugated hyperbilirubinemia caused by defective transport of conjugated bilirubin into the bile canaliculi. The defect is in the MRP2 (multidrug resistance-associated protein 2) transporter, not in UDP glucuronyl transferase (which is deficient in Crigler-Najjar syndrome) or hepatic uptake (defective in Rotor syndrome). The liver appears black due to melanin-like pigment deposition.

Keep practicing — related questions