Multiple choice

The basis for development of leukemia in some children treated with a retrovirus-derived gene therapy vector is

  1. stimulation of immune response to cell surface antigens introduced by an inserted gene

  2. insertional mutation of a tumor suppressor gene

  3. use of a virus that contains an oncogene

  4. insertion of the viral genome adjacent to an oncogene
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Insertion of a retrovirus adjacent to an oncogene can activate that gene and lead to malignant transformation.

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