Multiple choice

Which among the following statements does NOT characterise HIV viral antigen?

  1. Serum antibodies form the first layer of protection of the host from viral infection.

  2. Recombinant viral proteins are expressed in bacteria, yeast, mammalian cells, etc.

  3. Recombinant viral protein usually contains a fusion protein.

  4. Recombinant viral antigens contain part of viral sequence.

  5. ELISAs provide a valuable tool in the detection and diagnosis of viral infection.
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A Correct answer
Explanation

Antibody-based immune responses form a first layer of protection of the host from viral infection; however, in many cases a vigorous cellular immune response mediated by T-cells and NK-cells is required for effective viral clearance. When cellular immunity is unable to clear the virus, the infection can become chronic, and serum antibodies to the viral pathogen are used as first indicator for the diagnosis of the disease.

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