Multiple choice

Which of the following HIV antigens provides a potential target for neutralising antibodies produced in the host?

  1. U3

  2. gp120

  3. Reverse transcriptase

  4. Protease

  5. Tat
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

gp120 is an envelope protein which binds to CD4 on the T-cell. Antibodies to the V3 loop of gp120 arise during the disease and are particularly effective as neutralising agents in vitro, although less so in vivo. Generally, neutralising antibodies are more effective against HIV-2 than against HIV-1.

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