Multiple choice

Mr. Verma is suffering from pancreatic carcinoma. In pancreatic carcinoma, the ras gene

  1. is absent

  2. is normal but is overexpressed

  3. has a large deletion

  4. contains a single point mutation, always at the same position

  5. contains a single point mutation, but not always at the same position
Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

Point mutation leads to a single amino acid substitution at either position 12, 13 or 61. These mutations are found in over 90% of patients with pancreatic carcinomas, in 40% of patients with colorectal cancers and their preneoplastic lesions, in acute myeloid leukemia (AML) and in preleukemic syndromes.

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