Multiple choice

Which of the following is most commonly seen in African children with Burkitt's lymphoma?

  1. Chromosome 8q24 to Chromosome 2p12 translocation

  2. Chromosome 8q24 to Chromosome 14q32 translocation

  3. Deletion of the c-myc gene

  4. T-cell neoplasia

  5. Absence of EBV

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B Correct answer
Explanation

The c-myc gene (chromosome 8q24) involved in the entry of cells from resting G0 into the cell cycle is translocated to the mu heavy chain gene (chromosome 14q32) in most cases of Burkitt's lymphoma studied.