Multiple choice

Which of the following malignancies is due to the chromosomal translocation?

  1. Lung cancer

  2. Chronic lymphoblastic leukemia

  3. Acute myelocytic leukemia

  4. Chronic myelogenous leukemia

  5. Bladder cancer

Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Chronic myelogenous leukemia (CML) is caused by the Philadelphia chromosome, resulting from a reciprocal translocation between chromosomes 9 and 22 - t(9;22)(q34;q11). This creates the BCR-ABL fusion gene with constitutive tyrosine kinase activity. Other malignancies listed have different causes (lung cancer from mutations, CLL from various genetic changes, AML from multiple mutations, bladder cancer from environmental factors).

Keep practicing — related questions