Multiple choice

Which type of mutation would not be expected to be detected in a molecular diagnostic test that is based on sequencing each exon of a gene in genomic DNA from a male suspected of having an X-linked disorder?

  1. Missense mutation

  2. Nonsense mutation

  3. Deletion of an exon

  4. Inversion of part of the gene
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Yes, the inversion of part of gene cannot be detected . As it would not cause the exons to be absent or missing, and the sequencing reaction would not reveal that the exons are no longer arranged in the proper order on genomic DNA.

 

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