Human Biology: Genetics, Anatomy, and Physiology
This test is of biology which helps students to prepare for board exams of class XI & XII, .Also this contributes a major portion of Biology Syllabus of AIPMT.
Questions
Which of the following is the usual treatment of hemophilia A?
- Infusion of factor VIII as needed
- Blood transfusion
- Liver transplant
- Bone marrow transplant
Which type of mutation would not be expected to be detected in a molecular diagnostic test that is based on sequencing each exon of a gene in genomic DNA from a male suspected of having an X-linked disorder?
- Missense mutation
- Nonsense mutation
- Deletion of an exon
- Inversion of part of the gene
What are Amsterdam criteria used to assess?
- Risk of hereditary nonpolyposis colon cancer.
- Risk of familial adenomatosis polyposis.
- Risk of hereditary breast and ovarian cancer.
- Risk of Cowden syndrome.
What is the major mechanism of HER-2/neu oncogene activation in breast cancer?
- Gene amplification
- Point mutation
- Translocation
- Deletion
What does clinical validity refer to?
- The accuracy with which a test identifies a mutation in a genetic variant present or absent.
- The accuracy with which a test identifies a mutation, which correctly predicts the presence or absence of a disease.
- The accuracy with which a test predicts the absence or presence of a gene.
- The accuracy with which a test can provide the prevention of a disease.
Polymorphism in the gene encoding a sodium channel, is associated with which of the following complications of treatment with specific drugs?
- Seizures
- Cardiac arrhythmia
- Renal damage
- Cirrhosis of the liver
The basement membrane lies between the
- stratum basale and stratum spinosum
- stratum spinosum and stratum granulosum
- stratum granulosum and stratum corneum
- epidermis and dermis
Which of the following strata consist of dead and desquamating cells?
- Stratum corneum
- Stratum germinativum.
- Stratum basale
- Stratum spinosum
The ducts in the male reproductive system are lined by ______________.
- simple squamous epithelium
- transitional epithelium
- cuboidal epithelium
- a pseudostratified columnar epithelium
Mutation in the RET oncogene is associated with increased risk of _____________.
- colon cancer
- medullary thyroid cancer
- endometrial cancer
- prostate cancer
Which of the following corpuscles respond to deep pressure?
- Merkel's touch corpuscles
- Meissner's corpuscles
- Pacinian corpuscles
- Renal corpuscle
The cells that participate in the process of bone development and bone remodelling are _________.
- plasma cells
- osteocytes
- osteoblasts
- osteoclasts
Inflammationa is a local response to cellular injury marked redness, pain, swelling etc. What stimulates this process?
- Fibroblasts
- Adipocytes
- Mast cells
- Lymphocytes
Which of the following cell is involved in neural encoding of tactile sensation ?
- Melanocyte
- Langerhans cells
- Merkel cells
- Keratinocytes
Which of the following is associated with mutation of genes involved in mismatch DNA repair?
- Cervical cancer
- Neurofibromatosis type 1
- Von Hippel-Lindau Syndrome
- Hereditary nonpolyposis colon cancer