Tag: chemical coordination and integration

Endocrine glands----> hormones-----> blood----> organs / tissues----> biochemical / physiological activity.

In feed back inhibition product of a reaction inhibits the enzyme catalysing that reaction. It is a type of control mechanism at the enzyme level. If the product is produced in sufficient amount, it inhibits the enzyme to stop the further production. So, the correct answer is 'End product'.

Accumulation of end products triggers an inhibiting action as a feedback inhibition of the metabolic pathway causing its inhibition. as a result, the metabolic pathway is switched off or halted. For example, the absence of the suckling stimulus leads to inhibition of the milk secretion.

Most hormones are regulated by feedback mechanisms. A feedback mechanism is a loop in which a product feeds back to control its own productions. Most negative feedback loops get involved from hormone feedback mechanisms. Here the time delay occurs and hormones are released.

There are two sets of nerve cells in the hypothalamus that produce hormones.

The feedback mechanism is the process wherein the upregulation and downregulation of genes, hormones, homoeostasis and other factors are controlled. For example, if the level of sugar concentration in blood has increased feedback mechanism upregulates the hormone insulin which helps to stabilise the sugar in the blood. 

One distinctive feature of hormones whose secretion is regulated through the hypothalamus and pituitary is that they regulate their own secretion through negative feedback inhibition. CRH (corticotropin releasing hormone) and ACTH (adrenocorticotropic hormone). Less tropic hormone secretion leads to less stimulation of cortisol secretion by cells of the zona fasciculata of the adrenal cortex. The usefulness of negative feedback inhibition is that it works to keep hormone levels within a particular appropriate physiological range.  The reduced negative feedback inhibition means that more CRH and ACTH will be secreted. More ACTH will stimulate the remaining adrenal tissue to grow and to secrete more cortisol. This will have the effect of bringing cortisol back up towards its normal daily level of secretion.

The hypothalamus and pituitary that triggered the female reproductive cycle do not schedule milk production on a nine-month clock basis. But oxytocin is released due to the stimulation by fetal ejection reflex. By this stimulation, oxytocin is released which causes contraction in uterus wall and also stimulates prolactin secretion for milk production in mammary gland. Thus, the correct answer is option D.

Allosteric inhibition is the regulation of an enzyme by an effector molecule that binds to a site other than the active site, which is called allosteric site. Since it is not blocking the active site it is called 'positive feedback' option $(B)$