Multiple choice general knowledge How many sets of chromosomes do humans have 21 22 23 24 Reveal answer Fill a bubble to check yourself C Correct answer Explanation Humans have 23 pairs of chromosomes (46 total). 22 pairs are autosomes and 1 pair is sex chromosomes (XX in females, XY in males). Each pair contains one chromosome from each parent. Options 21, 22, and 24 are incorrect.