Multiple choice The Bubonic plague was spread by _______. rats infested with fleas carrying the bacterium. poisoned water from the town wells. an overall drop in temperatures known as a “little ice age.” the Great Famine. Reveal answer Fill a bubble to check yourself A Correct answer Explanation The Bubonic Plague was transmitted by fleas that lived on rats; these fleas carried the bacterium Yersinia pestis and spread it to humans.