Multiple choice Which two systems work together to maintain homeostasis? the endocrine system and the nervous system The receptor system and the effector system the central nervous system and the peripheral nervous system the digestive system and the respiratory system Reveal answer Fill a bubble to check yourself A Correct answer Explanation The nervous system and the endocrine system are the two primary control systems that communicate throughout the body to maintain homeostasis. The nervous system uses electrical signals, while the endocrine system uses hormones.