Multiple choice

Daptomycin is bactericidal against Gram-positive bacteria. Which of the following functions is/are inhibited due to its action?

a. DNA synthesis b. RNA synthesis c. Protein synthesis

  1. Only a and c

  2. Only b

  3. Only a and b

  4. All of the above
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

This is the correct answer. Daptomycin disrupts multiple aspects of bacterial cell membrane function. It inserts into the cell membrane and alters the curvature of the membrane, which creates holes that leak ions. This causes rapid depolarisation that results in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis. This results in bacterial cell death.

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