Multiple choice general knowledge history Who was the actress opposite to Cruise in Jerry Maguire? Renee Zellweger Katie Holmes Penelope Cruz Nicole Kidman Reveal answer Fill a bubble to check yourself A Correct answer Explanation Renee Zellweger played Dorothy Boyd opposite Tom Cruise's Jerry Maguire in the 1996 film. Katie Holmes, Penelope Cruz, and Nicole Kidman are all actresses who worked with Cruise but in different films.