Which of the following statements are FALSE?

P. Paralogs are genes in different species that are diverged from a common ancestral sequence, as a result of the speciation. Q. PSI-BLAST builds profiles and performs data base searches in an iterative fashion. R. A domain may or may not include motifs within its boundaries. S. Motifs and domains are evolutionarily less conserved than other regions of a protein and tend to evolve as units.

Yes, this is the correct answer.  Mutations in the upstream or downstream regions can cause differential regulation without actually changing the function of the gene. Such homolog genes in one genome are called paralogs. Orthologs are genes in different species that diverge from a common ancestral sequence as a result of the speciation. Motifs and domains are evolutionarily more conserved than other regions of a protein and tend to evolve as units, which are gained, lost, or shuffled as one module.