Multiple choice

The phenomenon in which following successful Ig gene rearrangement, further rearrangement on the sister chromatid is suppressed, is termed as

  1. class switching

  2. productive rearrangement

  3. clonal selection

  4. allelic exclusion

  5. gene shuffling
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D Correct answer
Explanation

All of the immunoglobulin gene loci (heavy, kappa light, lambda light) exhibit allelic exclusion, as do all of the T-cell receptor gene loci, except the alpha chain. Thus, a B-cell is able to express only one light and one heavy chain specificity.

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