Multiple choice

In a thymectomized organism, which of the following is irradiated and reconstituted with bone marrow cells?

  1. The T-lymphocyte population is not restored.

  2. The B-lymphocyte population is not restored.

  3. All lymphocyte populations are restored.

  4. None of the lymphocyte populations are restored.

  5. Rapid death inevitably follows.
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A Correct answer
Explanation

Immature lymphocytes which are destined to become T-cells travel from the bone marrow to the thymus where they differentiate to immunocompetence and are educated to recognize peptides derived from foreign antigens presented by self MHC molecules. Thus in a thymectomized animal, this process cannot take place.

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