Multiple choice

Which of the following enzymes is responsible for inducing cleavage of a single double-stranded DNA molecule between the antigen receptor coding segment and a flanking recombination signal sequence?

  1. DNA-dependent protein kinase (DNA-Pk)

  2. Artemis nuclease

  3. Terminal deoxynucleotidyl transferase (TdT)

  4. Recombination activating gene (RAG)

Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

RAG enzymes work as a multi-subunit complex to induce cleavage of a single double-stranded DNA (dsDNA) molecule between the antigen receptor coding segment and a flanking recombination signal sequence.