Immunology (GATE - XL)
Immune system components including complement proteins, antibodies, immune cells, cytokines, and immune mechanisms
Questions
Veiled cells function in chemokine-production, cross presentation and IFN alpha production. They are found in the
- nose
- skin
- blood
- stomach
Which of the following complement proteins are anaphylotoxins?
- C3a, C4a, C5a
- C1a, C2a, C3a
- C1b, C2b, C3b
- C3b, C4b, C5b
What role does secreted phospholipases A2 play in immune system?
- Development of B and T lymphocytes
- Attraction of lymphocytes to infected site
- Chemoattractant
- Inflammation
Which of the following complement proteins are involved in the process of opsonisation?
- C4a and C5a
- C4b and C3b
- C4a and C3a
- C5a and C6-C9
Which complement protein is measured for supporting the diagnosis of post-infectious glomerulonephritis?
- Complement component 1
- Complement component 3
- Complement component 5
- Complement component 6
Which of the following is the principle effector function of IgM?
- Neonatal immunity
- Mucosal immunity
- Complement activation
- Immunity against helminths
Defensins are a family of mammalian host defence peptides. They manifest their antimicrobial action and provide primary immunity to
- skin
- oral cavity
- eyes
- ears
Factor H is a member of complement activation family. It functions as
- anaphylotoxin
- opsonin
- control protein
- decay accelerating factor (DAF)
Mast cells express a high-affinity receptor (FcεRI). This receptor is for
- IgA antibodies
- IgE antibodies
- IgM antibodies
- IgD antibodies
Which of the following enzymes is responsible for inducing cleavage of a single double-stranded DNA molecule between the antigen receptor coding segment and a flanking recombination signal sequence?
- DNA-dependent protein kinase (DNA-Pk)
- Artemis nuclease
- Terminal deoxynucleotidyl transferase (TdT)
- Recombination activating gene (RAG)
Myeloperoxidases (MPO) are used by immune cells to kill bacteria and other pathogens. They are expressed in
- basophils
- neutrophils
- eosinophils
- monocytes
Which complement factor is associated with C1q deficiency which occurs due to formation of C1q antibodies?
- Partial lipodystrophy
- Type II membranoproliferative glomerulonephritis (MPGN II)
- Hypocomplementemic urticarial vasculitis syndrome (HUVS)
- Systemic lupus erythematosus (SLE)
Some animals possess distinct Ig heavy chain which results in different antibodies. In which animals are IgW antibodies found?
- Frogs
- Lungfish
- Zebrafish
- Sharks
Which class of HLA proteins are just restricted to macrophages and lymphocytes?
- Class I HLA
- Class II HLA
- Class III HLA
- Class IV HLA
Which interferon can be used to treat hepatitis B and C infections?
- IFN-beta
- IFN-alpha
- IFN-kappa
- IFN-omega