Albinism is caused by defective melanin production due to deficiency of the enzyme tyrosinase (also called tyrosine 3-monooxygenase). This enzyme converts tyrosine to DOPA in the melanin synthesis pathway. Without functional tyrosinase, melanin cannot be produced, resulting in absence of pigment in skin, hair, and eyes. The other enzymes listed are involved in different metabolic pathways: homogentisic acid oxidase in tyrosine breakdown, phenylalanine hydroxylase in phenylalanine metabolism, and thiamine pyrophosphate is a coenzyme.