Multiple choice

Increase in maternal serum AFP levels is seen in which one of the following?

  1. Down's syndrome

  2. Molar pregnancy

  3. Over estimated gestational age

  4. Congenital Nephrotic Syndrome
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D Correct answer
Explanation

Maternal serum AFP is elevated in open fetal neural tube defects, abdominal wall defects, and congenital nephrotic syndrome (due to fetal protein loss). In Down's syndrome, AFP is decreased. Molar pregnancy shows variable patterns but not typically elevation. Overestimated gestational age would show lower levels.

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