Multiple choice

What is true about linkage analysis in familial gene disorders?

  1. Characteristic DNA polymorphism in a family is associated with disorders.

  2. Characteristic DNA polymorphism with a clinical phenotype.

  3. Useful to make pedigree chart to show affected and non-affected family members.

  4. Used to make a pedigree chart to show non-paternity.
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A Correct answer
Explanation

Linkage analysis tracks DNA polymorphisms (markers) that co-segregate with a disease phenotype within families. It identifies chromosomal regions harboring disease genes by observing inheritance patterns. It doesn't directly make pedigree charts (that's done separately) or detect non-paternity.

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