Multiple choice

Senile cardiac amyloidosis is due to defect in

  1. �2 - microglobulin

  2. transthyretin

  3. AANF

  4. pyrin
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Senile cardiac amyloidosis is caused by deposition of transthyretin (TTR) amyloid in the heart, particularly in elderly patients. This is distinct from secondary amyloidosis (AA protein from chronic inflammation) and dialysis-associated amyloidosis (beta-2 microglobulin). Transthyretin is a transport protein produced in the liver that can misfold and deposit as amyloid fibrils.

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