Multiple choice

The mutations in the NaK2Cl transporter in the loop of Henle causes

  1. Liddle's syndrome

  2. Pseudohypoaldosteronism

  3. nephrogenic diabetes insipidus

  4. Gitelman's syndrome

  5. Barrter's syndrome
Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

In Barrter's syndrome there is a mutation, which inhibits the activity of the NaK2Cl cotransporter. It is the molecule normally inhibited by frusemide. The clinical effects of Barrter''s syndrome are therefore the same as excess frusemide and include loss of sodium, potassium and water. The bodies response to this is to raise aldosterone levels in an attempt to conserve sodium.

Keep practicing — related questions