Multiple choice

Polysomy of sex chromosomes in an individual is induced by successive nondisjunctions in meiosis I and II. Polysomy in which of the following chromosomes causes squamous cell carcinoma in human beings?

  1. Chromosome 17

  2. Tetrasomy 18p

  3. Tetrasomy 9p

  4. Chromosome 7

  5. Trisomy 21

Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

In squamous cell carcinoma, a protein from the epidermal growth factor receptor (EGFR) gene is often overexpressed in conjunction with polysomy of chromosome 7, so chromosome 7 can be used to predict the presence of EGFR in squamous cell carcinoma.