Polysomy of sex chromosomes in an individual is induced by successive nondisjunctions in meiosis I and II. Polysomy in which of the following chromosomes causes squamous cell carcinoma in human beings?
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Chromosome 17
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Tetrasomy 18p
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Tetrasomy 9p
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Chromosome 7
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Trisomy 21
D
Correct answer
Explanation
In squamous cell carcinoma, a protein from the epidermal growth factor receptor (EGFR) gene is often overexpressed in conjunction with polysomy of chromosome 7, so chromosome 7 can be used to predict the presence of EGFR in squamous cell carcinoma.