Multiple choice

Polysomy of sex chromosomes in an individual is induced by successive nondisjunctions in meiosis I and II. The squamous cell carcinoma is associated with _____________________.

  1. Trisomy 21

  2. Chromosome 7

  3. Tetrasomy 9p

  4. Tetrasomy 18p

  5. Chromosome 17

Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

In squamous cell carcinoma, a protein from the epidermal growth factor receptor (EGFR) gene is often overexpressed in conjunction with polysomy of chromosome 7, so chromosome 7 can be used to predict the presence of EGFR in squamous cell carcinoma.