Multiple choice

Fosfomycin is a cell wall inhibitor. Which of the following steps of peptidoglycan synthesis is inhibited by fosfomycin?

  1. Fru 6-P to GlcN 6-P

  2. UDP-GlcNAc to UDP-MurNAc

  3. UDP-MurNAc-tripeptide to UDP-MurNAc-pentapeptide

  4. UDP-MurNAc to UDP-MurNAc-tripeptide
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Fosfomycin inhibits conversion of UDP-GlcNAc to UDP-MurNAc. This is the first committed step in peptidoglycan biosynthesis, so amenable to selective action.

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