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Antibiotics and Other Chemotherapeutic Agents (GATE ...

Covers antibiotic mechanisms of action, bacterial resistance, clinical uses, and classification of chemotherapeutic agents including antibacterial, antiviral, antifungal, and antitumor drugs

15 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

Transmission of resistance to antibiotics takes place by R-factor which is present in the plasmids. In enteric pathogens, the transmission takes place through E. coli. Which of the following is a weak recipient of the R-factor from an E. coli donor?

  1. Klebsiella
  2. Salmonella
  3. Proteus
  4. Shigella
Question 2 Multiple Choice (Single Answer)

Nalidixic acid is used in the treatment of which of the following conditions?

  1. Tuberculosis
  2. Urinary tract infections
  3. Dermatological infections
  4. Fungal infections
Question 3 Multiple Choice (Single Answer)

Which of the following antibiotics acts by blocking pyridoxine and nicotinamide catalyzed reactions?

  1. Rifampicin
  2. Nitrofurantoin
  3. Ethambutol
  4. Isoniazid
Question 4 Multiple Choice (Single Answer)

Interferons are chemotherapeutic agents for treating viral infections. Chemically, interferons are

  1. polypeptides
  2. glycoproteins
  3. phospholipids
  4. glycolipids
Question 5 Multiple Choice (Single Answer)

Which type of antibiotic is anthramycin?

  1. Anti-fungal antibiotic
  2. Anti-mycobacterial antibiotic
  3. Anti-tumor antibiotic
  4. Broad spectrum antibiotic
Question 6 Multiple Choice (Single Answer)

Exposing bacterial cells to high osmotic pressure halts the activity of which antibiotic?

  1. Polymyxin
  2. Erythromycin
  3. Penicillin
  4. Sulfonamide
Question 7 Multiple Choice (Single Answer)

Erythromycin belonging to the macrolide group manifests its action by

  1. binding to 23S rRNA component of 50S subunit of the ribosome
  2. binding to 5S rRNA component of 50S subunit of the ribosome
  3. binding to 30S subunit of 70S ribosome
  4. binding to peptidyl transferase enzyme
Question 8 Multiple Choice (Single Answer)

Fosfomycin is a cell wall inhibitor. Which of the following steps of peptidoglycan synthesis is inhibited by fosfomycin?

  1. Fru 6-P to GlcN 6-P
  2. UDP-GlcNAc to UDP-MurNAc
  3. UDP-MurNAc-tripeptide to UDP-MurNAc-pentapeptide
  4. UDP-MurNAc to UDP-MurNAc-tripeptide
Question 9 Multiple Choice (Single Answer)

Which of the following differs from all the protein synthesis inhibitors?

  1. Kanamycin
  2. Gentamycin
  3. Lincomycin
  4. Tobramycin
Question 10 Multiple Choice (Single Answer)

Which group of antibiotics binds DNA gyrase to inhibit nucleic acid synthesis?

  1. Rifamycins
  2. Quinolones
  3. Nitrofurans
  4. Antifolates
Question 11 Multiple Choice (Single Answer)

Which of the following is a protozoal DHFR (Dihydrofolate reductase) inhibiting chemotherapeutic agent?

  1. Trimethoprim
  2. Pyrimethamine
  3. Pemetrexed
  4. Methotrexate
Question 12 Multiple Choice (Single Answer)

Which two organisms can be distinguished by using the antibiotic bacitracin?

  1. S. pyogenes from other beta hemolytic bacteria
  2. S. pyogenes from S. pneumoniae
  3. S. aureus from S. epidermis
  4. S. pyogenes from S. aureus
Question 13 Multiple Choice (Single Answer)

Which of the following are susceptible to monobactams?

  1. Aerobic gram positive bacteria
  2. Anaerobic gram negative bacteria
  3. Aerobic gram negative bacteria
  4. Anaerobic gram positive bacteria
Question 14 Multiple Choice (Single Answer)

Match the following:
Antibiotic Target
1. Tomaymycin a. Virus
2. Amatadine b. Bacteria
3. Griseofulvin c. Tumor
4. Gallidermin d. Fungus
  1. |||
    |---|---|
    |1. Tomaymycin|a. Virus|
    |2. Amatadine|c. Tumor|
    |3. Griseofulvin|b. Bacteria|
    |4. Gallidermin|d. Fungus|
  2. |||
    |---|---|
    |1. Tomaymycin|c. Tumor|
    |2. Amatadine|a. Virus|
    |3. Griseofulvin|d. Fungus|
    |4. Gallidermin|b. Bacteria|
  3. |||
    |---|---|
    |1. Tomaymycin|b. Bacteria|
    |2. Amatadine|d. Fungus|
    |3. Griseofulvin|a. Virus|
    |4. Gallidermin|c. Tumor|
  4. |||
    |---|---|
    |1. Tomaymycin|d. Fungus|
    |2. Amatadine|b. Bacteria|
    |3. Griseofulvin|c. Tumor|
    |4. Gallidermin|a. Virus|
Question 15 Multiple Choice (Single Answer)

Match the antibiotics with the organisms that produce them:
Antibiotic Organism
1. Chlorotetracycline a. Streptomyces noursei
2. Streptomycin b. Streptomyces aureofaciens
3. Nystatin c. Streptomyces orientalis
4. Vancomycin d. Streptomyces griseus
  1. |||
    |---|---|
    |1. Chlorotetracycline|c. Streptomyces orientalis|
    |2. Streptomycin|a. Streptomyces noursei|
    |3. Nystatin|b. Streptomyces aureofaciens|
    |4. Vancomycin|d. Streptomyces griseus|
  2. |||
    |---|---|
    |1. Chlorotetracycline|a. Streptomyces noursei|
    |2. Streptomycin|c. Streptomyces orientalis|
    |3. Nystatin|d. Streptomyces griseus|
    |4. Vancomycin|b. Streptomyces aureofaciens|
  3. |||
    |---|---|
    |1. Chlorotetracycline|b. Streptomyces aureofaciens|
    |2. Streptomycin|d. Streptomyces griseus|
    |3. Nystatin|a. Streptomyces noursei|
    |4. Vancomycin|c. Streptomyces orientalis|
  4. |||
    |---|---|
    |1. Chlorotetracycline|a. Streptomyces noursei|
    |2. Streptomycin|b. Streptomyces aureofaciens|
    |3. Nystatin|c. Streptomyces orientalis|
    |4. Vancomycin|d. Streptomyces griseus|
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