Multiple choice

Which of the following changes in the cell causes inflammation, which is a defensive reaction initiated by infection or tissue injury?

  1. Upregulation of adhesion molecules on endothelial cells and leukocytes

  2. Chemotaxis

  3. IL-8 release

  4. Phagocytosis

  5. Bacterial killing
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A Correct answer
Explanation

Up-regulation of P-selectin leads to binding to sialyl Lewisx on the neutrophil and causes rolling along the endothelium. Upregulation of PAF leads to firm binding to the receptor on the neutrophil and the cell is then subject to chemotactic attraction to pass through the endothelial cells.

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