Multiple choice

Which of the following compounds suppresses racemization & enhances the efficiency of peptide synthesis?

  1. Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

  2. Hydroxybenzotriazole

  3. 1-Hydroxy-7-azabenzotriazole

  4. N,N-Diisopropylcarbodiimide
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B Correct answer
Explanation

Hydroxybenzotriazole is an organic compound that is a derivative of benzotriazole. It is mainly used to suppress racemization and improve the efficiency of peptide synthesis. It is a white crystalline powder. Commercial it always contains some water (~11.7% wt as the HOBT monohydrate crystal) because it is explosive.

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