Among the following ------------------- is a first-line diuretic drug ?
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(2S,4R)-4-Hydroxyproline
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Hydrochlorothiazide
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Histamine
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Serotonin
B
Correct answer
Explanation
Hydrochlorothiazide is a first-line diuretic drug of the thiazide class that acts by inhibiting the kidneys' ability to retain water. This reduces the volume of the blood, decreasing blood return to the heart and thus cardiac output and by other mechanisms, is believed to lower peripheral vascular resistance.