Multiple choice

Which of the following amino acids is a disruptor of secondary structure of protein?

  1. Glycine

  2. Phenylalanine

  3. Proline

  4. Glutamate
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C Correct answer
Explanation

Proline is a structural disruptor of protein secondary structure because its side chain forms a ring with the backbone nitrogen, making it an imino acid. This rigid ring prevents the rotation and phi angle needed for alpha-helices and beta-sheets, often creating kinks or terminating secondary structure elements.

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