Multiple choice

Regarding the cancer genome sequencing, which among the following statements is incorrect?

  1. Cancer genome sequencing is the whole genome sequencing of a single, homogeneous or heterogeneous group of cancer cells.

  2. Cancer genome sequencing involves direct sequencing of primary tumor tissue.

  3. Cancer genome sequencing is not limited to WG sequencing.

  4. Cancers are homogeneous populations of cells.

  5. Cancer genome sequencing provides clinically relevant information in patients with rare tumor types.
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D Correct answer
Explanation

Cancers are heterogeneous populations of cells. When sequence data is derived from a whole tumor, information about the differences in sequence and expression pattern between cells is lost. This difficulty can be ameliorated by single-cell analysis.

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