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Genome Sequencing and Human Genome Project

Test your knowledge of DNA sequencing technologies, genome analysis methods, DNA profiling techniques, and genomic research tools including microarrays and high-throughput sequencing.

11 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

Which among the following statements regarding the differential extraction of DNA is incorrect?

  1. This method is used in the extraction of DNA from vaginal epithelial cells.
  2. Differential extraction disrupt the peptide bonds present in the coating of the sperm cell.
  3. Through this process, the DNA from two different types of cells can be extracted without mixing their contents.
  4. The first part of the differential lysis is carried out under mild conditions to gain the female DNA.
  5. Due to the high yield of DNA, the chance of a successful DNA-profile by downstream analysis is significantly increased.
Question 2 Multiple Choice (Single Answer)

Which of the following DNA profiling techniques is employed where a differential extraction of DNA is not possible?

  1. RFLP analysis (Restriction fragment length polymorphism)
  2. PCR analysis (polymerase chain reaction)
  3. STR analysis (Short tandem repeats)
  4. AmpFLP (Amplified fragment length polymorphism)
  5. Y-chromosome analysis
Question 3 Multiple Choice (Single Answer)

In humans the TYMP gene encodes the enzyme thymidine phosphorylase. The mitochondrial disease caused by mutations in the TYMP gene is _________________.

  1. mitochondrial neurogastrointestinal encephalopathy syndrome
  2. Leigh disease
  3. multiple sclerosis
  4. Wolff-Parkinson-White syndrome
  5. diabetes mellitus and deafness
Question 4 Multiple Choice (Single Answer)

Which among the following methods of sequencing DNA produces information about both identity and location of nucleotide sequences within the genome of an individual?

  1. Transposon sequencing
  2. Deep sequencing
  3. Exome sequencing
  4. Positional sequencing
  5. MicroRNA sequencing
Question 5 Multiple Choice (Single Answer)

Which among the whole-genome sequencing methods has the capability to target multiple genes simultaneously?

  1. Polymerase chain reaction
  2. Molecular inversion probe
  3. Hybrid capture
  4. In-solution capture
  5. Sequencing
Question 6 Multiple Choice (Single Answer)

Zero-mode waveguides illuminates the process of translation. It is used by _______________ type of DNA sequencing.

  1. shotgun sequencing
  2. single cell sequencing
  3. single molecule fluorescent sequencing
  4. single molecule real time sequencing
  5. magnetic sequencing
Question 7 Multiple Choice (Single Answer)

DNA microarray analysis is one of the fastest-growing new technologies in the field of genetic research. Which among the following statements does not characterizes the process of DNA microarray?

  1. DNA microarrays involves the hybridization between two DNA strands.
  2. DNA microarrays can be used to detect single nucleotide polymorphisms.
  3. DNA microarray experiment can accomplish many genetic tests in parallel.
  4. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, platinum -, or chemiluminescence-labeled targets.
  5. A DNA microarray is a collection of microscopic DNA spots attached to a solid surface.
Question 8 Multiple Choice (Single Answer)

Which among the following DNA-modifying enzymes is regarded as a type of molecular motor?

  1. DNA ligases
  2. Topoisomerases
  3. Helicases
  4. Polymerases
  5. Nucleases
Question 9 Multiple Choice (Single Answer)

The method covalently linking the proteins of interest to the mRNAs encoding them is ____________________.

  1. in-vitro virus high-throughput sequencing
  2. RNAP sequencing
  3. transmission electron microscopy DNA sequencing
  4. microfluidic Sanger sequencing
  5. sequencing with mass spectrometry
Question 10 Multiple Choice (Single Answer)

Regarding the cancer genome sequencing, which among the following statements is incorrect?

  1. Cancer genome sequencing is the whole genome sequencing of a single, homogeneous or heterogeneous group of cancer cells.
  2. Cancer genome sequencing involves direct sequencing of primary tumor tissue.
  3. Cancer genome sequencing is not limited to WG sequencing.
  4. Cancers are homogeneous populations of cells.
  5. Cancer genome sequencing provides clinically relevant information in patients with rare tumor types.
Question 11 Multiple Choice (Single Answer)

The DNA profiling method used extensively by the scientists to identify genes whose expression is altered in response to pathogens is ______________.

  1. GeneID
  2. comparative genomic hybridization
  3. gene expression profiling
  4. fusion genes microarray
  5. genome tiling arrays
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