Which among the following is an autosomal recessive metabolic genetic disorder?
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Sickle-cell disease
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Cystic fibrosis
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Tay-Sachs disease
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Phenylketonuria
D
Correct answer
Explanation
Phenylketonuria (PKU) is an autosomal recessive metabolic genetic disorder characterized by an error in the genetic code for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.This enzyme is necessary to metabolize the amino acid phenylalanine (Phe) to the amino acid tyrosine.