During Jahangir's reign (1605-1627), the Persian Safavid Empire seized Kandahar from Mughal control in 1622. This loss occurred after Jahangir's governor of Kandahar defected to the Persians, marking a significant territorial setback for the Mughal Empire. The loss of Kandahar would remain a point of contention between the Mughals and Persians for decades.