Which one of the following is true of congenital abnormalities seen in the newborn baby?

Deformations are typically due to an insult in the first trimester whereas malformations occur due to insults in the second or third trimester.

Congenital anomaly allows researchers to identify clusters of abnormality and may allow earlier identification of a teratogenic source.

Deformities of the skull bones are extremely rare and need urgent neurosurgical referral.

An abnormal uterus or breech position does not cause limb abnormalities to occur.

Talipes equinovarus responds best to early corrective surgery by an orthopaedic surgeon.