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Human Reproduction and Biotechnology Applications

This test covers human reproductive biology, pregnancy, childbirth, and applications of biotechnology including genetic engineering, mutations, and molecular biology techniques.

13 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

Which of the following statements regarding genetic engineering is incorrect?

  1. Genetic engineering does not normally include traditional animal and plant breeding.
  2. If genetic material from another species is added to the host, the resulting organism is called cisgenic.
  3. Genetic engineering alters the genetic make-up of an organism.
  4. It involves macro-injection and micro-encapsulation techniques.
  5. Gene targeting uses homologous recombination.
Question 2 Multiple Choice (Single Answer)

The mutations forming nonsense codon in the transcribed mRNA is ________________.

  1. frameshift mutation
  2. nonsense mutation
  3. missense mutations
  4. neutral mutation
  5. silent mutations
Question 3 Multiple Choice (Single Answer)

In humans, certain specific diseases are caused by point mutations. Which among the following diseases is associated with HEXA gene being present on chromosome 15?

  1. Color blindness
  2. Tay–Sachs disease
  3. Sickle-cell anemia
  4. Neurofibromatosis
  5. Cystic fibrosis
Question 4 Multiple Choice (Single Answer)

The mechanism of transcription capable of interacting between RNA polymerase and a particular promoter is ___________.

  1. silencers
  2. specificity factors
  3. activators
  4. general transcription factors
  5. enhancers
Question 5 Multiple Choice (Single Answer)

Which among the following mutations has no effect on the functioning of the protein?

  1. Silent mutations
  2. Nonsense mutations
  3. Missense mutations
  4. Non-conservative mutations
  5. Conservative mutations
Question 6 Multiple Choice (Single Answer)

Which of the following statements is false regarding normal birth in humans?

  1. As the uterus contracts, blood flow through the uterine artery is interrupted.
  2. Fetal blood oxygen levels can be 4 – 6 kPa (30 – 45 mmHg) without causing brain damage.
  3. The fetal brain can use alternative fuels such as ketones, if the supply of glucose is interrupted.  
  4. The umbilical arterial pH is the same or higher than the venous pH.
  5. Most babies are cyanosed at birth.
Question 7 Multiple Choice (Single Answer)

The process of transcription can be recognised by different methods. The relative abundance of freshly established transcripts is frequently measured by ________________.

  1. nuclear Run-on assay
  2. RT-PCR
  3. DNA microarrays
  4. RNA-Seq
  5. RNase protection assay
Question 8 Multiple Choice (Single Answer)

Which one of the following is true of congenital abnormalities seen in the newborn baby?

  1. Deformations are typically due to an insult in the first trimester whereas malformations occur due to insults in the second or third trimester.
  2. Congenital anomaly allows researchers to identify clusters of abnormality and may allow earlier identification of a teratogenic source.
  3. Deformities of the skull bones are extremely rare and need urgent neurosurgical referral.
  4. An abnormal uterus or breech position does not cause limb abnormalities to occur.
  5. Talipes equinovarus responds best to early corrective surgery by an orthopaedic surgeon.
Question 9 Multiple Choice (Single Answer)

Which among the following microarrays is utilised by the scientists to produce a global picture of cellular function?

  1. Gene expression profiling
  2. DamID
  3. SNP array
  4. Fusion genes microarray
  5. Tiling array
Question 10 Multiple Choice (Single Answer)

In a woman a twin pregnancy is identified at 12 weeks' gestation. One placenta and one separate amniotic sac are identified. In which of the following scenarios, is this is most likely to arise?

  1. Ovulation induction
  2. ICSI with single embryo transfer
  3. Natural conception
  4. Family history of multiple pregnancy in sister
  5. Maternal age 35 – 39 years
Question 11 Multiple Choice (Single Answer)

Autism is a neurodevelopmental disorder in children. Who discovered the first monogenic mutations involved in autism?

  1. Hermann J. Muller
  2. Gustave Malecot
  3. Antoine Danchin
  4. Monod
  5. Thomas Bourgeron
Question 12 Multiple Choice (Single Answer)

Which one of the following pregnancies carries the highest risk of adverse outcome?  

  1. Singleton pregnancy
  2. Dichorionic diamniotic twins
  3. Monochorionic diamniotic twins
  4. Monochorionic monoamniotic twins
  5. Disappearing twin
Question 13 Multiple Choice (Single Answer)

Which of the following translocation leads to the formation of one large metacentric chromosome and one extremely minute chromosome in an individual?

  1. Inversion
  2. Whole-arm translocation
  3. Reciprocal translocation
  4. Simple Translocation
  5. Robertsonian translocation
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