Multiple choice

In genetics, the process of gene conversion is regarded as the mechanism responsible for the separation of species. Which among the following statements does not characterise gene conversion?

  1. Conversion of one allele to the other is often due to base mismatch repair during hetrozygous recombination.

  2. Meiotic recombination is initiated through formation of a double-strand break.

  3. One of these 3’ single stranded DNA segments forms an intermediate.

  4. In Synthesis Dependent Strand Annealing (SDSA), there is information exchange but not physical exchange.

  5. Gene conversion may occur during recombinational repair involving a DHJ.
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A Correct answer
Explanation

Conversion of one allele to the other is often due to base mismatch repair during homologous recombination: if one of the four chromatids during meiosis pairs up with another chromatid, as can occur because of sequence homology, DNA strand transfer can occur followed by mismatch repair. This can alter the sequence of one of the chromosomes, so that it is identical to the other.

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