Multiple choice

Which of the following statements regarding the TCA is incorrect?

  1. In TCA, citrate is used for feedback inhibition.

  2. The citrate goes through a series of chemical transformations, losing two carboxyl groups as HCO3-.

  3. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced.

  4. The regulation of the TCA cycle is largely determined by product inhibition and substrate availability.

  5. The major eventual substrate of the cycle is ADP.
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The citrate goes through a series of chemical transformations, losing two carboxyl groups as CO2. The carbons donated by acetyl-CoA become part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle.  

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