Multiple choice general knowledge science & technology

Sickle-cell anaemia is caused due to point mutation of :

  1. Alinine to Aspartic acid

  2. Aspartic acid to Alanine

  3. Valine to Glutamic acid

  4. Glutamic acid to Valine
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D Correct answer
Explanation

Sickle-cell anemia results from a point mutation where Glutamic acid is replaced by Valine at position 6 of the beta-globin chain (Glu6Val mutation). This single amino acid change causes hemoglobin to polymerize under low oxygen, deforming red blood cells into sickle shapes.

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